Anti-PTPN11 Mouse Monoclonal Antibody [clone: 5F2]

Toimittaja: AbFrontier
Anti-PTPN11 Mouse Monoclonal Antibody [clone: 5F2]
SHP2 is a tyrosine phosphatase containing two tandem SH2 (src homology 2) domains. Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules.
SHP1 and SHP2 represent a subfamily of non-transmembrane PTPs that contain two SH2 domains followed by a PTP domain. Tyrosine phosphorylation of SHP2 is required for normal ERK activation in response to some growth factors. In the inactive state, the N-terminal SH2 domain binds the PTP domain and blocks access of potential substrates to the active site. This auto-inhibition is relieved by the binding of phosphopeptides to SH2 domain, resulting in activation of phostphatase activity.
Noonan syndrome characterized by an abnormal face, short stature and cardiac abnormalities is due to the mutations of N-terminal SH2 domain or PTP domain. SHP2 mutations might also cause some leukemia, and could be important in pathogenesis by Helicobacter pylori, the major cause of gastric ulcer and carcinoma.

Western Blot: 1:2,000; Immunoprecipitation: 1 ?l;

Type: Primary
Antigen: PTPN11 (protein tyrosine phosphatase, non-receptor type 11)
Clonality: Monoclonal
Clone: 5F2
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human, Mouse, Rat
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