Anti-ACHE Mouse Monoclonal Antibody [clone: 3A5]

Toimittaja: AbFrontier
Anti-ACHE Mouse Monoclonal Antibody [clone: 3A5]
Acetylcholinesterase hydrolyzes the neurotransmitter acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. In addition, acetylcholinesterase contributes to various physiological processes through its involvement in the regulation of cell proliferation, differentiation and survival.
Because of alternative splicing at the C-terminus of acetylcholinesterase mRNA, it has three different isoforms: synaptic (S), erythrocytic (E) and read-through (R). These acetylcholinesterase variants selectively participate in the processes involved in promoting or attenuating cell death that accompany changes in expression, distribution and balance among the enzyme variants.
Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer’s disease (AD). AD is characterized by a loss of cholinergic neurons and their cortical projections from the nucleus basalis and associated areas in the basal forebrain.
The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain acetylcholinesterase (AChE) has been the major therapeutic target of cholinesterase inhibitor treatment strategies for Alzheimer's disease (AD).

Western Blot: 1:2,000;

Type: Primary
Antigen: ACHE (acetylcholinesterase (Yt blood group))
Clonality: Monoclonal
Clone: 3A5
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human, Rat
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Lue lisää About VWR