Anti-RIPK2 Mouse Monoclonal Antibody [clone: AF28D3]

Toimittaja: AbFrontier
Anti-RIPK2 Mouse Monoclonal Antibody [clone: AF28D3]
The RIP(receptor-interacting protein) family of serine/Threonine kinases(RIP-1,2,3,4,5,6,7) are crucial regulators of cell survival and cell death that can trigger pro-survival, inflammatory and immune responses via the activation of transcription factors(NF-kB and AP-1) and death-inducing programs.
RIP2(also known as RICK, CARDIAK, CCK and Ripk2) transduces signals from receptors of both immune responses. RIP2 carries a CARD at its C-terminal, which is essential for NF-kB activation. RIP2 is a critical downstream mediator of Nod1 and Nod2 signaling. Overexpression of RIP2 results in the activation of, in addition to NF-kB, the MAPKs JNK and ERK2, requiring its kinase activity to activate ERK2, but not JNK.

Western Blot: 1:2,000; Immunoprecipitation: 3 ?l;

Type: Primary
Antigen: RIPK2 (receptor-interacting serine-threonine kinase 2)
Clonality: Monoclonal
Clone: AF28D3
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human, Mouse, Rat
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