Anti-CD27 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: O323]

Toimittaja: Tonbo Biosciences
50-0279-T100EA 88.1 EUR
50-0279-T100 50-0279-T025
Anti-CD27 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: O323]
The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.

Type: Primary
Antigen: CD27 (CD27 molecule)
Clonality: monoclonal
Clone: O323
Conjugation: PE (Phycoerythrin)
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human
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