Anti-PDCD1 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)) [clone: J43]

Toimittaja: Tonbo Biosciences
50-9985-U100EA 128 EUR
50-9985-U100 50-9985-U025
Anti-PDCD1 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)) [clone: J43]
The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with “B7” ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

Type: Primary
Antigen: PDCD1 (programmed cell death 1)
Clonality: monoclonal
Clone: J43
Conjugation: PE (Phycoerythrin)
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse
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