Anti-ATG3 Rabbit Polyclonal Antibody

Toimittaja: Biosensis
BSENR-159-100EA 302 EUR
Anti-ATG3 Rabbit Polyclonal Antibody
FUNCTION: GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy. SUBUNIT: Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. SIMILARITY: Belongs to the ATG3 family.

IHC, WB and ELISA confirmed the specificity for ATG3. A 37kDa band, that corresponds to the molecular weight of ATG3, is detected via western blot analysis.
Application Information:
IHC, WB, immunofluorescence. A dilution of 1:50 to 1:3000 dilution is recommended for these applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: ATG3
Clonality: Polyclonal
Conjugation: Unconjugated
Epitope: central region of the Human ATG3
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat, Mouse
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