The Bcl-2 family of proteins which regulate apoptosis share identical sequences called Bcl-2 Homology domains (BH1-4). The BH3 proteins, including BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence identity within the amphipathic alpha-helical BH3 region, which is essential for their apoptotic function. NOXA is highly expressed in adult T-cell leukemia cell line.
Western blot analysis of cells infected with Noxa adenoviruses and BAF indicates a high level of specificity for this antiserum.
Application Information:
WB. A dilution of 1:1000 to 1:2000 is recommended for this application. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: Noxa
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Mouse Noxa (aa: 1-16)
Host: Rabbit
Isotype: IgG
Reactivity: Mouse