Anti-proBDNF Rabbit Polyclonal Antibody

Toimittaja: Biosensis
BSENR-176-20EA 260 EUR
BSENR-176-20
Anti-proBDNF Rabbit Polyclonal Antibody
Vasta-aineet
BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

Used in western blot, this antiserum detects a 35 kDa band corresponding to the molecular weight of proBDNF. No cross reactivity with other proneurotrophins was detected.
Application Information:
IHC, WB. 1-5 µg/ml is recommended for both applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: proBDNF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Human BDNF precursor protein (aa: 69-82)
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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