Anti-alpha synuclein Sheep Polyclonal Antibody

Toimittaja: Biosensis
BSENS-024-100EA 334 EUR
BSENS-024-100
Anti-alpha synuclein Sheep Polyclonal Antibody
Vasta-aineet
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.

Immunohistochemistry shows a high specificity for alpha-synuclein.
Application Information:
IHC with 1:1000 to 1:2000 dilution. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: alpha synuclein
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Human alpha synuclein (aa: 116-131)
Host: Sheep
Isotype: IgG
Reactivity: Human, Rat, Mouse
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