Anti-rh CNTF Sheep Polyclonal Antibody

Toimittaja: Biosensis
BSENS-025-100EA 334 EUR
BSENS-025-100
Anti-rh CNTF Sheep Polyclonal Antibody
Vasta-aineet
CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

This antibody specifically detects CNTF shown by western blot.
Application Information:
IHC, WB, ELISA. A dilution of 1:500 to 4000 is recommended for these applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: rh CNTF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Multiple epitopes because of the nature of the immunogen
Host: Sheep
Isotype: IgG
Reactivity: Rat, Mouse, Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Lue lisää About VWR