LMX-1.2 is essential for the specification of dorsal limb fate. It is expressed in most of tissues, with highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets. Defects in LMX-1.2 are the cause of nail-patella syndrome (NPS), also known as Onychoosteodysplasia. NPS is a disease that causes abnormal skeletal patterning and renal dysplasia. LIM homeodomain proteins are characterised by the presence of 2 tandem cysteine/histidine-rich, zinc-binding LIM domains.
Specificity has been confirmed by WB and direct ELISA against the antigen.
Application Information:
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: LMX-1.2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Human LMX-1.2 (1-110)
Host: Mouse
Isotype:
Reactivity: Human
