Neuropeptide VF is the precursor of neuropeptides NPSF (RFRP-1), RFRP-2 and RFRP-3 (NPVF). RFRP-3 is reported to inhibit forskolin-induced production of cAMP. RFRP-3 has also been shown to block morphine-induced analgesia.
Specificity was demonstrated by immunohistochemistry.
Application Information:
Immunohistochemistry (IHC). A concentration of 1 in 2000 is recommended. IHC performed in sheep brain (hypothalamus) demonstrates intense staining of cells and terminals. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: RFRP-3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: amino acids 124-131 from Human Neuropeptide VF.
Host: Guinea Pig
Isotype: IgG
Reactivity: Rat, Sheep