Anti-AP2-Beta Mouse Monoclonal Antibody [clone: 3G5-1D11]

Toimittaja: Biosensis
BSENM-872-100EA 327 EUR
Anti-AP2-Beta Mouse Monoclonal Antibody [clone: 3G5-1D11]
AP2-beta is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes during early development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes. AP2-beta appears to be required for normal face and limb development and for proper termnal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. It can form homodimers or heterodimers with other AP-2 family members. Defects in AP2-beta are the cause of Char syndrome (CHAR) which is characterised by patent ductus anteriosus (PDA), facial dysmorphism and hand anomalies.

Specificity has been confirmed by WB and direct ELISA against the antigen.
Application Information:
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: AP2-Beta
Clonality: Monoclonal
Clone: 3G5-1D11
Conjugation: Unconjugated
Host: Mouse
Reactivity: Human
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