Anti-Necdin Mouse Monoclonal Antibody [clone: 1B3]

Toimittaja: Biosensis
BSENM-847-100EA 327 EUR
BSENM-847-100
Anti-Necdin Mouse Monoclonal Antibody [clone: 1B3]
Vasta-aineet
Necdin is a growth suppressor that facilitates the entry of the cell into cell cycle arrest. It represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. Defecs in necdin may be the cause of the Prader-Willi syndrome which is characterised by muscular hypotonia, mental retardation, short stature, obesity, hypogonadotropic hypogonadism, and small hands and feet.

Specificity has been confirmed by WB and direct ELISA against the antigen.
Application Information:
This antibody is recommended for WB, IHC, sandwich ELISA and immunofluorescence. The recommended dilution for this antibody is 1 µg/ml for IHC and 10 µg/ml for immunofluorescence. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: Necdin
Clonality: Monoclonal
Clone: 1B3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human
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