Anti-NeuroD1 Mouse Monoclonal Antibody [clone: 3H8]

Toimittaja: Biosensis
BSENM-850-100EA 327 EUR
Anti-NeuroD1 Mouse Monoclonal Antibody [clone: 3H8]
NeuroD1 is a differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. It is a transcriptional activator and binds to the insulin gene E-box. Efficient DNA binding requires dimerisation with another basic helix-loop-helix protein. In islet cells, NeuroD1 is phosphoryated on Ser-274 upon glucose stimulation and in activated neurons it is phosphorylated on Ser-335, which promotes dendritic growth. Defects in NeuroD1 cause maturity onset diabetes of the young type 6 (MODY6). It is characterised by the onset of diabetes during young adulthood and a primary defect in insulin secretion.

Specificity has been confirmed by WB and direct ELISA against the antigen.
Application Information:
This antibody is recommended for WB, IHC, sandwich ELISA and immunofluorescence. The recommended dilution for this antibody is 3 µg/ml for IHC and 10 µg/ml for immunofluorescence. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: NeuroD1
Clonality: Monoclonal
Clone: 3H8
Conjugation: Unconjugated
Host: Mouse
Reactivity: Human
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