Anti-ATG7 Rabbit Polyclonal Antibody

Toimittaja: Biosensis
BSENR-161-100EA 334 EUR
BSENR-161-100
Anti-ATG7 Rabbit Polyclonal Antibody
Vasta-aineet
FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy. SUBUNIT: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. SUBCELLULAR LOCATION: Cytoplasm (Probable). ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12. SIMILARITY: Belongs to the ATG7 family. In yeast, ATG7 appears to be required for fusion of peroxisomal and vaculuolar membranes.

IHC, WB and ELISA confirmed the specificity for ATG7.
Application Information:
IHC, immunofluorescence. A dilution of 1:200 to 1:3000 dilution is recommended for these applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: ATG7
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-terminal of Human APG7 protein
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat
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