This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
This antibody stains cholinergic neurons in human, rat, guinea-pig and rabbit central and peripheral nervous systems.
Application Information:
IHC, 1 site ELISA. Use at a concentration of 1 µg/ml. This antiserum will superbly stain both cell bodies and nerve terminal. The optimal dilution should be determined by the end user.
Type: Primary
Antigen: ChAT
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: porcine ChAT protein (aa: 167-188)
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat, Guinea Pig, Rabbit
