Paclitaxel ≥98%, jauhe

Toimittaja: MP Biomedicals

ICNA0219353201EA 58.1 EUR
ICNA0219353201 ICNA0219353205 ICNA0219353225
Paclitaxel ≥98%, jauhe

Soluble in methanol (50 mg/ml - clear, colourless solution), DMSO (50 mg/ml - clear, colourless solution), chloroform and ethanol. DMSO solutions can be stored aliquoted and frozen at −20 °C for several months. Paclitaxel undergoes transesterification in methanol, and it hydrolyses in aqueous solutions; Hardly soluble in water.

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilises microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Kaava: C₄₇H₅₁NO₁₄
MDL numero: MFCD00869953
CAS-numero: 33069-62-4

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