Y-27632 (hydrochloride)

Toimittaja: Cayman Chemical
CAYM10005583-1EA 78 EUR
CAYM10005583-1 CAYM10005583-50 CAYM10005583-5 CAYM10005583-10
Y-27632 (hydrochloride)
Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nm) and ROCK-II (IC50 = 800 nm). It also inhibits PRK2 with an IC50 value of 600 nm.

  • Crystalline solid
  • Purity ≥98%
  • Storage at −20 °C

One-hour treatment with 10 µm Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passage.
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