Myostatin is an essential regulator of skeletal muscle mass and cardiac muscle development and function. It is also known as GDF-8, is a conserved member of the TGF-beta superfamily. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size.
- Produced from genetically modified E. coil
- Dimeric protein, containing 109/218 amino acids
Myostatin binds one of the two activin type II receptors (ACTRIIA or ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.
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