TAK-242 ≥98%

Toimittaja: Cayman Chemical

CAYM13871-5EA 303 EUR
CAYM13871-5 CAYM13871-25 CAYM13871-10 CAYM13871-1
TAK-242 ≥98%

Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response. Alternatively, hypoxia or ischemia/reperfusion can trigger signaling through TLR4. TAK-242 is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. It does not affect signaling through other TLRs.3,4,5 TAK-242 is effective in vivo, suppressing the production of NO, TNF-α, IL-6, and IL-1β in mice treated with LPS when given intravenously.3 Mechanistically, TAK-242 acts by selectively binding TLR4 and preventing its association with adaptor proteins that are essential for signal transduction. TAK-242 is used to study signaling through TLR4 in a variety of pathologies, including sepsis and ischemia/reperfusion injury.

Kaava: C₁₅H₁₇NO₄ClFS
MDL numero: MFCD11046362
CAS-numero: 243984-11-4

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